New way to identify inflammation occurring in eosinophil-related disorders
Diagnosing and monitoring both are an inflammatory gastrointestinal disease may soon become less invasive and more accurate. Gerald Gleich, Kristin Leifer man and Kathryn Peterson have developed a way to identify inflammation that occurs in eosinophil-related disorders such as eosinophilic esophagitis (EoE), a chronic and painful inflammatory condition of the esophagus can strike at any age. roughly 300,000 people in United States are affected by EoE are alone.
Eosinophils are a type of white blood cells that plays a major role in the body's immune system. Problems will arise if a person has a higher-than-normal number of eosinophils in their blood and/or if eosinophils infiltrate organs and tissues. EoE is the most common eosinophil-related illnesses and can currently only be diagnosed on biopsies of esophageal tissue obtained with observation via an endoscope, a camera attached to a flexible tube that is inserted into a patient's throat.
Endoscopies will be painful, time-consuming and inconclusive, and may carry some risks--all of which discourages patients from undergoing the procedure. Biopsies can also be falsely negative for example, all of the cells have broken apart and are no longer identifiable. Additionally, the disease is patchy and biopsies that only reflect to a small portion of the esophagus may miss areas of inflammation.
In addition to confirming that EoE is causing the pain, the imaging also will identify precisely where the affected tissue is in the esophagus and how much of the esophagus is affected.
NexEos, a new life-sciences startup based in Wayne, Pennsylvania, plans to advance and commercialize the diagnostic test developed by Gleich and his colleagues through a license from the U's Center for Technology & Venture Commercialization (TVC).
Eosinophils are a type of white blood cells that plays a major role in the body's immune system. Problems will arise if a person has a higher-than-normal number of eosinophils in their blood and/or if eosinophils infiltrate organs and tissues. EoE is the most common eosinophil-related illnesses and can currently only be diagnosed on biopsies of esophageal tissue obtained with observation via an endoscope, a camera attached to a flexible tube that is inserted into a patient's throat.
Endoscopies will be painful, time-consuming and inconclusive, and may carry some risks--all of which discourages patients from undergoing the procedure. Biopsies can also be falsely negative for example, all of the cells have broken apart and are no longer identifiable. Additionally, the disease is patchy and biopsies that only reflect to a small portion of the esophagus may miss areas of inflammation.
In addition to confirming that EoE is causing the pain, the imaging also will identify precisely where the affected tissue is in the esophagus and how much of the esophagus is affected.
NexEos, a new life-sciences startup based in Wayne, Pennsylvania, plans to advance and commercialize the diagnostic test developed by Gleich and his colleagues through a license from the U's Center for Technology & Venture Commercialization (TVC).
No comments:
Post a Comment